Abstract

Case Presentation

Osteopoikilosis: a rare case with interesting imaging

Nejadhosseinian Mohammad, Hadighi Pouya, Aghaghazvini Leila, Mozaffari Mohammad Ali, Babagoli Mazyar* and Faezi Seyedeh Tahereh

Published: 17 April, 2023 | Volume 7 - Issue 1 | Pages: 012-014

Background: Osteopoikilosis (OPK) is a rare osteosclerotic dysplasia. It is usually asymptomatic and diagnosis is made incidentally by radiographic findings. It has a unique radiographic presentation with multiple small, well-defined, circular, or ovoid radiodensities which are distributed symmetrically in the epiphysis and metaphysis of long bones.
Aim of the work: In this case report, a 38-year-old man with mild joint discomfort was diagnosed with OPK according to his radiographic findings and literature review.
Conclusion: It is important to diagnose OPK and to distinguish it from other medical conditions to calm the patient and to reduce unnecessary investigation.

Read Full Article HTML DOI: 10.29328/journal.acr.1001068 Cite this Article Read Full Article PDF

Keywords:

Osteopoikilosis; Bone scintigraphy; X-ray imaging

References

  1. Khot R. Osteopoikilosis: A case report. Indian Journal of Radiology and Imaging. 2005; 15(4): 453-454.
  2. Paraskevas G, Raikos A, Stavrakas M, Spanidou S, Papaziogas B. Osteopoikilosis: a case report of a symptomatic patient. J Radiol Case Rep. 2009;3(12):38-43. doi: 10.3941/jrcr.v3i12.260. Epub 2009 Dec 1. PMID: 22470634; PMCID: PMC3303288.
  3. Krishna D, Chand S. Osteopoikilosis: A case report with review of literature. Journal of Orthopedics, Traumatology and Rehabilitation. 2013; 6(1): 84.
  4. Baasanjav S, Jamsheer A, Kolanczyk M, Horn D, Latos T, Hoffmann K, Latos-Bielenska A, Mundlos S. Osteopoikilosis and multiple exostoses caused by novel mutations in LEMD3 and EXT1 genes respectively--coincidence within one family. BMC Med Genet. 2010 Jul 9;11:110. doi: 10.1186/1471-2350-11-110. PMID: 20618940; PMCID: PMC2912259.
  5. Roberts NM, Langtry JA, Branfoot AC, Gleeson J, Staughton RC. Case report: osteopoikilosis and the Buschke-Ollendorff syndrome. Br J Radiol. 1993 May;66(785):468-70. doi: 10.1259/0007-1285-66-785-468. PMID: 8391368.
  6. Hellemans J, Preobrazhenska O, Willaert A, Debeer P, Verdonk PC, Costa T, Janssens K, Menten B, Van Roy N, Vermeulen SJ, Savarirayan R, Van Hul W, Vanhoenacker F, Huylebroeck D, De Paepe A, Naeyaert JM, Vandesompele J, Speleman F, Verschueren K, Coucke PJ, Mortier GR. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nat Genet. 2004 Nov;36(11):1213-8. doi: 10.1038/ng1453. Epub 2004 Oct 17. PMID: 15489854.
  7. Chatterjee P, Sureka J, Joseph E, Sudhakar S, Chittaranjan S. Intraosseus and extraosseus juxtaarticular calcification: Osteopoikilosis with synovial osteochondromatosis - an association. J Radiol Case Rep. 2009;3(3):1-5. doi: 10.3941/jrcr.v3i3.138. Epub 2009 Mar 1. PMID: 22470645; PMCID: PMC3303297.
  8. Benli IT, Akalin S, Boysan E, Mumcu EF, Kiş M, Türkoğlu D. Epidemiological, clinical and radiological aspects of osteopoikilosis. J Bone Joint Surg Br. 1992 Jul;74(4):504-6. doi: 10.1302/0301-620X.74B4.1624505. Erratum in: J Bone Joint Surg [Br] 1994 Jul;76(4):683. PMID: 1624505.
  9. Carpintero P, Abad JA, Serrano P, Serrano JA, Rodríguez P, Castro L. Clinical features of ten cases of osteopoikilosis. Clin Rheumatol. 2004 Dec;23(6):505-8. doi: 10.1007/s10067-004-0935-2. PMID: 15801069.
  10. Lagier R, Mbakop A, Bigler A. Osteopoikilosis: a radiological and pathological study. Skeletal Radiol. 1984;11(3):161-8. doi: 10.1007/BF00349489. PMID: 6719141.
  11. Mungovan JA, Tung GA, Lambiase RE, Noto RB, Davis RP. Tc-99m MDP uptake in osteopoikilosis. Clin Nucl Med. 1994 Jan;19(1):6-8. doi: 10.1097/00003072-199401000-00002. PMID: 8137588.
  12. 1016/j.injury.2015.02.005. Epub 2015 Feb 11. PMID: 25707878.
  13. Woyciechowsky TG, Monticielo MR, Keiserman B, Monticielo OA. Osteopoikilosis: what does the rheumatologist must know about it? Clin Rheumatol. 2012 Apr;31(4):745-8. doi: 10.1007/s10067-011-1916-x. Epub 2012 Jan 14. PMID: 22246417.

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  • Osteopoikilosis: a rare case with interesting imaging
    Nejadhosseinian Mohammad, Hadighi Pouya, Aghaghazvini Leila, Mozaffari Mohammad Ali, Babagoli Mazyar* and Faezi Seyedeh Tahereh Nejadhosseinian Mohammad, Hadighi Pouya, Aghaghazvini Leila, Mozaffari Mohammad Ali, Babagoli Mazyar*, Faezi Seyedeh Tahereh. Osteopoikilosis: a rare case with interesting imaging. . 2023 doi: 10.29328/journal.acr.1001068; 7: 012-014

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