Abstract

Case Report

Case – Late Presentation of Invasive Keratinizing Squamous Cell Carcinoma

Maximilien Laviolette-Brassard* and Le Mai Tu

Published: 27 December, 2023 | Volume 7 - Issue 3 | Pages: 080-082

Penile cancer, a rare but highly morbid disease, primarily manifests as squamous cell carcinoma (PSCC) originating from the squamous cells of the glandular and preputial skin. Late-stage diagnosis is common due to social stigma, psychological barriers, and nonspecific initial symptoms, resulting in poor overall survival rates, especially in metastatic cases. This case report illustrates a 38-year-old man with advanced metastatic PSCC, showcasing severe systemic manifestations and delayed presentation of the disease. Despite aggressive treatment options, the patient opted for palliative care, succumbing to the disease months after his diagnosis. 
Risk factors for PSCC include HPV infection, phimosis, chronic inflammation, and lifestyle factors, with higher prevalence in regions of low socioeconomic status. The psychological and sexual burden of penile cancer is significant, impacting patients’ well-being, mental health, and quality of life. 
In conclusion, efforts to reduce the stigma associated with penile cancer are crucial to prompt early diagnosis and treatment initiation. Encouraging seeking medical attention for symptoms can enhance the chances of recovery and minimize the need for invasive treatments. Addressing the psychosocial impact of the disease is imperative for holistic patient care.

Read Full Article HTML DOI: 10.29328/journal.acr.1001084 Cite this Article Read Full Article PDF

Keywords:

Penile cancer; Squamous cell carcinoma; Diagnosis, Metastatic; Screening; Stigma; Quality of life; Risk factors

References

  1. Montes Cardona CE, García-Perdomo HA. Incidence of penile cancer worldwide: systematic review and meta-analysis. Rev Panam Salud Publica. 2017 Nov 30;41:e117. doi: 10.26633/RPSP.2017.117. PMID: 31384255; PMCID: PMC6645409.
  2. Thomas A, Necchi A, Muneer A, Tobias-Machado M, Tran ATH, Van Rompuy AS, Spiess PE, Albersen M. Penile cancer. Nat Rev Dis Primers. 2021 Feb 11;7(1):11. doi: 10.1038/s41572-021-00246-5. PMID: 33574340.
  3. Cubilla AL, Reuter V, Velazquez E, Piris A, Saito S, Young RH. Histologic classification of penile carcinoma and its relation to outcome in 61 patients with primary resection. Int J Surg Pathol. 2001 Apr;9(2):111-20. doi: 10.1177/106689690100900204. PMID: 11484498.
  4. Cubilla, A. L., Velazquez, E. F., Amin, M. B., Epstein, J., Berney, D. M., Corbishley, C. M., & Panel, M. of the I. P. T. (2018). The World Health Organisation 2016 classification of penile carcinomas: A review and update from the International Society of Urological Pathology expert-driven recommendations. Histopathology, 72(6), 893–904. https://doi.org/10.1111/his.13429
  5. Djajadiningrat RS, Graafland NM, van Werkhoven E, Meinhardt W, Bex A, van der Poel HG, van Boven HH, Valdés Olmos RA, Horenblas S. Contemporary management of regional nodes in penile cancer-improvement of survival? J Urol. 2014 Jan;191(1):68-73. doi: 10.1016/j.juro.2013.07.088. Epub 2013 Aug 2. PMID: 23917166.
  6. Lucky MA, Rogers B, Parr NJ. Referrals into a dedicated British penile cancer centre and sources of possible delay. Sex Transm Infect. 2009 Dec;85(7):527-30. doi: 10.1136/sti.2009.036061. Epub 2009 Jul 6. PMID: 19584061.
  7. Stecca CE, Alt M, Jiang DM, Chung P, Crook JM, Kulkarni GS, Sridhar SS. Recent Advances in the Management of Penile Cancer: A Contemporary Review of the Literature. Oncol Ther. 2021 Jun;9(1):21-39. doi: 10.1007/s40487-020-00135-z. Epub 2021 Jan 16. PMID: 33454930; PMCID: PMC8140030.
  8. Skeppner E, Andersson SO, Johansson JE, Windahl T. Initial symptoms and delay in patients with penile carcinoma. Scand J Urol Nephrol. 2012 Oct;46(5):319-25. doi: 10.3109/00365599.2012.677473. Epub 2012 Jul 2. PMID: 22989150.
  9. Vieira CB, Feitoza L, Pinho J, Teixeira-Júnior A, Lages J, Calixto J, Coelho R, Nogueira L, Cunha I, Soares F, Silva GEB. Profile of patients with penile cancer in the region with the highest worldwide incidence. Sci Rep. 2020 Feb 19;10(1):2965. doi: 10.1038/s41598-020-59831-5. PMID: 32076037; PMCID: PMC7031540.
  10. Pagliaro LC, Crook J. Multimodality therapy in penile cancer: when and which treatments? World J Urol. 2009 Apr;27(2):221-5. doi: 10.1007/s00345-008-0310-z. Epub 2008 Aug 6. PMID: 18682961; PMCID: PMC4164341.
  11. Dräger DL, Milerski S, Sievert KD, Hakenberg OW. Psychosoziale Auswirkungen bei Patienten mit Peniskarzinom : Ein systematischer Überblick [Psychosocial effects in patients with penile cancer : A systematic review]. Urologe A. 2018 Apr;57(4):444-452. German. doi: 10.1007/s00120-018-0603-9. PMID: 29476193.
  12. Dräger DL, Protzel C, Hakenberg OW. Identifying Psychosocial Distress and Stressors Using Distress-screening Instruments in Patients With Localized and Advanced Penile Cancer. Clin Genitourin Cancer. 2017 Oct;15(5):605-609. doi: 10.1016/j.clgc.2017.04.010. Epub 2017 Apr 21. PMID: 28499559.
  13. Maddineni SB, Lau MM, Sangar VK. Identifying the needs of penile cancer sufferers: a systematic review of the quality of life, psychosexual and psychosocial literature in penile cancer. BMC Urol. 2009 Aug 8;9:8. doi: 10.1186/1471-2490-9-8. PMID: 19664235; PMCID: PMC2731105.
  14. Audenet F, Sfakianos JP. Psychosocial impact of penile carcinoma. Transl Androl Urol. 2017 Oct;6(5):874-878. doi: 10.21037/tau.2017.07.24. PMID: 29184785; PMCID: PMC5673805.

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