Abstract

Case Report

Two Endocrine Disorders, One Postpartum Period: “The Coexistence of Thyroiditis and Hypophysitis,” A Case Report

Hatice Beyazal Polat*

Published: 24 December, 2024 | Volume 8 - Issue 3 | Pages: 163-166

The postpartum period is a phase during which various endocrine disorders may arise due to changes in the immune system. Postpartum thyroiditis and postpartum hypophysitis (lymphocytic hypophysitis) are two autoimmune diseases that typically occur independently but are rarely found together in the same patient.
Postpartum thyroiditis usually starts with thyrotoxicosis and progresses to hypothyroidism, while postpartum hypophysitis can lead to adrenal insufficiency and dysfunction of other pituitary hormones.
This case report discusses a female patient who presented with severe headaches, fatigue, and hypotension five months after childbirth. The patient was diagnosed with both postpartum thyroiditis and postpartum hypophysitis simultaneously, and dysfunction of both the thyroid and pituitary was detected. Hormone replacement therapies were administered, and the patient’s symptoms were brought under control.
This case emphasizes the importance of carefully evaluating both thyroid and pituitary function during the postpartum period. Early diagnosis and appropriate treatment are crucial for preventing potential complications and improving long-term health outcomes.

Read Full Article HTML DOI: 10.29328/journal.acr.1001118 Cite this Article Read Full Article PDF

Keywords:

Thyroiditis; Hypophysitis; Postpartum period; Autoimmune inflammation; Hormone replacement therapy

References

  1. Świątkowska-Stodulska R, Berlińska A, Stefańska K, Zieliński M, Kwiatkowski S, Połom J, et al. Endocrine Autoimmunity in Pregnancy. Front Immunol. 2022;13:907561. Available from: https://doi.org/10.3389/fimmu.2022.907561
  2. Kang JR, Cox R, Kluesner J. Postpartum Thyroiditis Mimicking Central Hypothyroidism: The Perfect Thyming. Cureus. 2023;15(7):e42630. Available from: https://doi.org/10.7759/cureus.42630
  3. Rad NS, Deluxe L. Postpartum Thyroiditis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024;PMID: 32491578. Free Books & Documents. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557646/
  4. Prete A, Salvatori R. Hypophysitis. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519842/
  5. Mizuno S, Inaba H, Kobayashi KI, Kubo K, Ito S, Hirobata T, et al. A case of postpartum thyroiditis following SARS-CoV-2 infection. Endocr J. 2021;68(3):371-374. Available from:https://doi.org/10.1507/endocrj.ej20-0553
  6. Kouzu H, Yano T, Nagano N, Koyama M, Ogawa T, Fujita Y, et al. Postpartum Heart Failure Complicated With Thyroiditis: A Concealed Aggravator of Peripartum Cardiomyopathy? Can J Cardiol. 2019;35(6):796.e1-796.e3. Available from:https://doi.org/10.1016/j.cjca.2019.03.013
  7. Costanza F, Cicia M, Giampietro A, Tartaglione T, Angelini F, Zoli A, et al. Pregnancy in Autoimmune Hypophysitis: Management of a Rare Condition. Endocr Metab Immune Disord Drug Targets. 2024. Available from: https://doi.org/10.2174/0118715303314953240719044233
  8. Baral B, Sharma M, Khadka R, Naveed O, Bekele A. Postpartum Hypophysitis: A Case Report and a Literature Review. Cureus. 2024;16(4):e59396. Available from: https://doi.org/10.7759/cureus.59396
  9. Costanza F, Cicia M, Giampietro A, Tartaglione T, Angelini F, Zoli A, et al. Pregnancy in Autoimmune Hypophysitis: Management of a Rare Condition. Endocr Metab Immune Disord Drug Targets. 2024. Available from: https://doi.org/10.2174/0118715303314953240719044233
  10. Krishnappa B, Shah R, Memon SS, Diwaker C, Lila AR, Patil VA, et al. Glucocorticoid therapy as first-line treatment in primary hypophysitis: a systematic review and individual patient data meta-analysis. Endocr Connect. 2022;12(2):e220311. Available from: https://doi.org/10.1530/EC-22-0311

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